Will it hold up at commercial scale?
That's the hardest question in biomanufacturing.
We optimize how your target protein is expressed, and raise its yield well above the benchmark.
Gene sequence design and strain construction
Strains we develop are normally provided under a paid license agreement. Terms are agreed case by case.
From one milligram in a test tube to a manufacturing process. We develop fermentation and purification conditions with production in mind, from 1–10 L fermenters through pilot scale to commercial facilities.
Fermentation process development, scale-up and contract manufacturing
What our strain development and culture optimization deliver
Titer of our own protein, at our commercial plant
Technologies usedGene optimization + culture condition optimization
Share of target proteins where a Spiber strain outperformed the benchmark
Technologies usedGene optimization
Average yield gain over the benchmark
Technologies usedGene optimization
Highest gain among tested cases
Technologies usedGene optimization
* Success rates and improvement factors are Spiber's internal results, measured against benchmark strains. Results vary with the target protein and culture conditions.
Spiber set out to make protein materials that could replace conventional ones. Getting there meant building every step of protein manufacturing ourselves: designing sequences, constructing strains, fermenting, purifying and producing at scale.
That same capability is now open to you, for whatever you set out to make, all the way to commercial scale.
So whether you bring us a protein of your own, a material with new functions or a secreted protein, we can take it on, from a small possibility in the lab to reliable supply at commercial scale.
The researchers who develop your strain and your production process are involved from the beginning.
The team you meet first stays with your project to the end.
Not for the first conversation. Tell us what the protein does, the scale you need and where you are stuck. We go into details once an NDA is in place.
Let us know the intended use and the quality requirements. We assess what we can support project by project.
For strain development we work with bacteria. For contract manufacturing we accept BSL-1 microorganisms.
To raise production of your target protein, we optimize the gene sequence, introduce it into our host strains and evaluate expression in culture. Metabolic pathway engineering is not part of the service.
Anything from research-scale trial batches to pilot and commercial production. Tell us what you need and how you make it today.
Pricing depends on the scope of strain development, process development and manufacturing. After the initial consultation we send you an individual quotation.
Describe your project in a few lines. You won't need to share a sequence.